Prior to his most renowned vehicle, The Mark Thomas Comedy Product, Thomas was the resident stand-up comic on Saturday Zoo, a Channel 4 comedy series first screened in 1993. He also presented the highly successful BBC Radio 1 talk show Loose Talk and is also a founder member of the London Comedy Store's hard hitting Cutting Edge show.
His political comedy shows, The Mark Thomas Comedy Product and The Mark Thomas Product on Channel 4 earned him criticism from politicians but were seen by critics as a crucial investigative tool. Leaving Channel 4 was a mutual decision, following a series of disputes over how far the channel would go in its broadcasting, one of which concerned the channel's reluctance to support actions concerning corporate accountability and corporate manslaughter laws - a cause he had campaigned for - which coincided with the Queen Mother's funeral.
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