Charcot-Marie-Tooth disease, also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy, is a heterogeneous inherited disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in the advanced stages of disease. Though presently incurable, this disease is one of the most common inherited neurological disorders, with 36 in 100,000 affected (Krajewski et al.,2000).

Description

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The disorder is caused by the absence of molecules that are essential for normal function of the nerves due to deficiencies in the structure of the genes coding these molecules. The absence of these chemical substances gives rise to dysfunction either in the axon or the myelin sheath of the nerve cell.

The different classes of this disorder have been divided into the primary demyelinating neuropathies (CMT1, CMT3, and CMT4) and the primary axonal neuropathies (CMT2). Recent studies, however, show that the pathologies of these two classes are frequently intermingled, due to the dependence and close cellular interaction of Schwann cells and neurons. Schwann cells are responsible for myelin formation, enwrapping neural axons with their plama membranes in a process called “myelination” (Berger et al., 2002).

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@JNHLover rt my son has charcot-marie-tooth disease. he had both feet done in spokane at shiners hospital. so for a year
honybear (tammi perkins) Mon, 04 Jan 2010 18:42:20 -0000
@JNHLover rt my son has charcot-marie-tooth disease. he had both feet done in spokane at shiners hospital. so for a year
@jaamz2004 rt no no he has charcot-marie-tooth disease.he had his right foot done july 4 08 then he was down all summer
honybear (tammi perkins) Thu, 31 Dec 2009 16:42:15 -0000
@jaamz2004 rt no no he has charcot-marie-tooth disease.he had his right foot done july 4 08 then he was down all summer
Posted #stroke updt Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C.: http://bit.ly/65HNTj asktheneurologist
NeuroTweeter (NeuroTweeter) Tue, 29 Dec 2009 11:40:07 -0000
Posted #stroke updt Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C.: http://bit.ly/65HNTj asktheneurologist

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